Downregulation of mouse intestinal Na(+)-coupled glucose transporter SGLT1 by gum arabic (Acacia Senegal).

Renal and extrarenal effects of gum arabic ( Acacia senegal )--what can be learned from animal experiments?

Gum arabic (GA), a water-soluble dietary fiber rich in Ca(2+), Mg(2+) and K(+), is used in Middle Eastern countries for the treatment of patients with chronic kidney disease. Recent animal experiments shed some light into mechanisms involved in the therapeutic action of GA. According to experiments in healthy mice, GA treatment increases creatinine clearance, enhances renal excretion of ADH, Mg...

Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance.

We have investigated the mechanisms of regulation of the Na+/glucose co-transporter (SGLT1) in a ruminant animal, which is an exceptional model system for studying intestinal glucose transport. Pre-ruminant lambs absorb glucose, produced by hydrolysis of the milk sugar lactose, in the intestine via apical SGLT1 and basolateral facilitative glucose transporters (GLUT2). Weaning coincides with th...

Gum Arabic: More Than an Edible Emulsifier

Gum Arabic (GA) or Acacia gum is an edible biopolymer obtained as exudates of mature trees of Acacia senegal and Acacia seyal which grow principally in the African region of Sahe in Sudan. The exudate is a non-viscous liquid, rich in soluble fibers, and its emanation from the stems and branches usually occurs under stress conditions such as drought, poor soil fertility, and injury (Williams & P...

(i) DEGRADATIVE AND ANALYTICAL STUDIES OF PLANT GUM EXUDATES WITH PARTICULAR REFERENCE TO GUM ARABIC (ACACIA SENEGAL) (ii) THE MECHANISM OF INTERACTION BETWEEN UNLIKE CELLULOSIC ETHERS AND GALACTOMANNANS

Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters

The absorption of glucose is electrogenic in the small intestinal epithelium. The major route for the transport of dietary glucose from intestinal lumen into enterocytes is the Na⁺/glucose cotransporter (SGLT1), although glucose transporter type 2 (GLUT2) may also play a role. The membrane potential of small intestinal epithelial cells (IEC) is important to regulate the activity of SGLT1. The m...